New trials in Canada showed that the long-term daily use (over 4 years) of finasteride (5 mg) and dutasteride in men aged 50 years and older was associated with a small but statistically significant increased risk of high-grade prostate cancer. The 1 mg finasteride strength (Propecia) was not included in these trials but a potential risk has not been ruled out.
The purpose of the clinical trials was to provide evidence in support of a new use for finasteride and dutasteride: to prevent prostate cancer. Both trials showed that the possible benefits of these drugs in preventing low-grade prostate cancer are small relative to the risk of developing high-grade prostate cancer.
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